This study was conducted with 16 randomized clinical trials investigating the effects of melatonin supplementation, compared to placebo, on fasting blood glucose, insulin resistance, and glycosylated hemoglobin in over 800 healthy subjects.
The doses of melatonin given ranged from 3 to 10 mg per day. Results indicate that 56% of the trial showed benefits of melatonin supplementation on diabetes parameters compared to placebo.
Ref.: Delpino FM, Figueiredo LM, Nunes BP. Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr. 2021 Jul;40(7):4595-4605. doi: 10.1016/j.clnu.2021.06.007. Epub 2021 Jun 16. PMID: 34229264.
