Interest in the potential cardiovascular benefits of Omega-3 polyunsaturated fatty acids began in the 1940s with several studies already demonstrating positive effects in relation to cardiovascular disease.
Today, Omega-3 intervention doses of 1 g/day of EPA + DHA continue to be used for various studies, which demonstrated significant benefits for cardiovascular disease in Italian and Japanese populations with a higher initial intake of Omega-3 in their regular diet. Patients from Western countries or countries with lower Omega-3 intake in general may require higher dose interventions to achieve a therapeutic effect of Omega-3.
There is clear evidence from multiple studies that higher doses of Omega-3 (2-4 g/day of EPA + DHA) appear to be safe and reduce cardiovascular disease events, warranting further studies to conclusively determine the potential benefits of Omega-3 supplementation, an inexpensive and well-tolerated treatment.
Ref: Elagizi A, Lavie CJ, O’Keefe E, Marshall K, O’Keefe JH, Milani RV. An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health. Nutrients. 2021 Jan 12;13(1):204. doi: 10.3390/nu13010204. PMID: 33445534; PMCID: PMC7827286. https://pubmed.ncbi.nlm.nih.gov/33445534/
